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Positively screened LBW toddlers had significantly higher parental age at conception, lower birth weight, higher frequency of small-for-gestational-age preterms as well as higher incidence of gestational bleeding when compared with negatively screened LBW. They also had lower language and social ages than the negatively screened LBW. M-CHAT scores of positively screened LBW children correlated positively with maternal age at conception and negatively with birth weight, social age, and language age. Five of the 11 positively screened LBW children and one of the two positively screened controls were confirmed to have autism on the basis of CARS.

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Its incidence has risen fold since the early s, with most of this increase not explainable by changing diagnostic criteria 4. It is now believed that the mechanism underlying autism etiology is most likely an interaction of environmental and genetic factors 6,7. Although the distinctive neuropathology remains elusive, studies have shown macroscopic, microscopic, and functional brain abnormalities, 6—8 which suggest that the etiologically relevant period may be in utero because the pathogenesis may begin during the prenatal period 6. Pregnancy-related exposures have been the focus of a significant amount of epidemiological research on possible risk factors for autism 9.

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