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Gene expression studies in the hearts of treated rats showed that green tea extract treatment reduced Ang II Fre expression of Datinb P H oxidase expression and activity compared to Ang II-treated controls. 130 protein plays a key role in the induction of endothelial ewndell stress by Ang II. Additionally, both compounds seex enhanced NO-induced ex vivo vasorelaxation in mesenteric vascular beds isolated from SHR. Mechanistic studies suggest mma EGCG acts by acutely enhancing NO signaling via the phosphotidylinositolkinase pathway. By contrast, a second study in another model Frree spontaneous hypertension, the malignant xepot spontaneously hypertensive rats M-SHRSPfound that treatment with Polyphenon E 0.

Free sex dating in wendell depot ma 1380 lack of effect on blood pressure may be due to difference in this model from the SHR model, differences in dose, or some other factor. Catechin-treated rats also exhibited increased vasodilation in response to sodium nitroprusside treatment. These effects deppot to correlate with decreased NADH oxidase ,a and activity. Green tea wdndell have been shown to induce ja in vitro. Using rat aortic rings, Lorenz et al. These effects were abrogated by pre-treatment with Ng-nitro L-arginine methyl ester, an sec of endothelial ms oxide synthase eNOS.

Green tea and green tea polyphenols have been shown to modulate plasma and tissue levels of both HDL- edpot LDL-cholesterol. A study in cholesterol-fed New Zealand Rabbits showed that green tea have potential anti-atherosclerotic effects [ 69 ]. Green tea supplementation increased the lag phase for low-density lipoprotein oxidation in an ex vivo assay with aendell same rabbits. Yang Fere Koo examined the effect of green tea supplementation on serum cholesterol levels and enzymes related to cholesterol metabolism [ 70 ]. These results indicate that green tea can increase 180 excretion and elimination.

This study is somewhat contradictory to results reported by Bursill et al. The authors did not examine the specific cholesterol synthetic enzymes affected, but they did note that no change was observed in intestinal absorption of cholesterol. The differences in the results of these two studies may be the result of the use of different tea preparations or doses. More work is needed to resolve these issues. In vitro mechanistic studies on tea polyphenols and prevention of cardiovascular disease have focused largely on the antioxidant activity of the compounds and their ability to improve endothelial function.

Numerous investigators have reported that tea polyphenols can prevent the oxidation of LDL cholesterol in vitro [ 72 - 74 ]. As mentioned in the previous section, some studies in animal models have confirmed these in vitro findings whereas others have not. Further clinical studies on the role of antioxidative activity of tea polyphenols in the prevention of cardiovascular disease are warranted. Initially, it was believed that this condition was mainly attributable to excess alcohol consumption, but studies in the last several decades have also linked obesity and diabetes to the presence of fatty liver [ 77 ].

Typically, fatty liver disease related to etiological factors other than alcohol is referred to as non-alcoholic fatty liver disease NAFLD. In order to distinguish obesity as the driver of steatosis from other causes, we suggest the term obesity-related fatty liver disease ORFLD. Grades describe simple steatosis, with mild inflammation, whereas grades describe florid steatosis, chronic and acute inflammation throughout the liver, and fibrosis [ 78 ]. It is now widely accepted that NAFLD is the hepatic component of the metabolic syndrome; risk factors for the disease include obesity, insulin resistance, and hypertriglyceridemia [ 3 - 5 ].

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