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Recognising changes in the brain that are indicative of epilepsy makes it possible to find increasingly efficient ways to treat and even prevent the disease. When working with patients, one often has to settle for not being able to make a diagnosis on the basis of MRI," Sierra Lopez says. She is keen on searching for MRI biomarkers to anticipate the development of epilepsy. With a five-year funding package from the Academy of Finland, she aims to apply novel MRI methods to studying the microstructure of the brain in order to find biomarkers of the precursors of epilepsy that is related to head injury.
Biomarkers can be very subtle changes in the brain which indicate that the development of epilepsy has begun. The development of epilepsy is documented in animals using MRI, and these findings are compared to changes observed in brain tissue samples. The project uses several MRI methods, including diffusion tensor imaging, and novel techniques, high-angular-resolution diffusion imaging, double-pulsed-field-gradient and sweep imaging with Fourier transformation.